A novel t(3;12)(q21;p13) translocation in a patient with accelerated chronic myeloid leukemia after imatinib and nilotinib therapy

A novel t(3;12)(q21;p13) translocation in a patient with accelerated chronic myeloid leukemia after imatinib and nilotinib therapy

The acquisition of secondary chromosomal aberrations in chronic myeloid leukemia (CML) patients with Philadelphia chromosome-positive (Ph+) karyotype signifies clonal evolution associated with the progression of the disease to its accelerated or blastic phase. Therefore, these aberrations have clini...

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Bibliographic Details
Main Authors: Ayda Bennour, Ikram Tabka, Yosra Ben Youssef, Zahra Kmeira, Abderrahim Khelif, Ali Saad, Halima Sennana
Format: Article
Language:English
Published: China Anti-Cancer Association 2013-03-01
Series:Cancer Biology & Medicine
Subjects:
Philadelphia chromosome
t(3
12)(q21
p13)
chronic myeloid leukemia
accelerated phase
fluorescence in situ hybridization
Online Access:http://www.cancerbiomed.org/index.php/cocr/article/view/590

Internet

http://www.cancerbiomed.org/index.php/cocr/article/view/590

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