NHR-14 loss of function couples intestinal iron uptake with innate immunity in C. elegans through PQM-1 signaling

NHR-14 loss of function couples intestinal iron uptake with innate immunity in C. elegans through PQM-1 signaling

Iron is essential for survival of most organisms. All organisms have thus developed mechanisms to sense, acquire and sequester iron. In C. elegans, iron uptake and sequestration are regulated by HIF-1. We previously showed that hif-1 mutants are developmentally delayed when grown under iron limitati...

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Bibliographic Details
Main Authors: Malini Rajan, Cole P Anderson, Paul M Rindler, Steven Joshua Romney, Maria C Ferreira dos Santos, Jason Gertz, Elizabeth A Leibold
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-09-01
Series:eLife
Subjects:
iron uptake
innate immunity
NHR-14
PQM-1
pathogen
SMF-3
Online Access:https://elifesciences.org/articles/44674

Internet

https://elifesciences.org/articles/44674

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