A systematic review of the role of eculizumab in systemic lupus erythematosus-associated thrombotic microangiopathy

A systematic review of the role of eculizumab in systemic lupus erythematosus-associated thrombotic microangiopathy

Abstract Background Lupus nephritis (LN) is a severe consequence of systemic lupus erythematosus (SLE) that affects approximately 40% of patients. Pathogenic immune complexes that are characteristic of LN deposit in the kidney and activate immune mediated pathways including the complement system. Co...

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Bibliographic Details
Main Authors: Rachael D. Wright, Fariba Bannerman, Michael W. Beresford, Louise Oni
Format: Article
Language:English
Published: BMC 2020-06-01
Series:BMC Nephrology
Subjects:
Lupus nephritis
Eculizumab
Complement
Thrombotic microangiopathy
Systematic review
Online Access:http://link.springer.com/article/10.1186/s12882-020-01888-5

Internet

http://link.springer.com/article/10.1186/s12882-020-01888-5

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