Protective efficacy of centralized and polyvalent envelope immunogens in an attenuated equine lentivirus vaccine.
Lentiviral Envelope (Env) antigenic variation and related immune evasion present major hurdles to effective vaccine development. Centralized Env immunogens that minimize the genetic distance between vaccine proteins and circulating viral isolates are an area of increasing study in HIV vaccinology. T...
Main Authors: | , , , , , , |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2015-01-01
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Series: | PLoS Pathogens |
Online Access: | http://europepmc.org/articles/PMC4287611?pdf=render |