Sericin-Induced Melanogenesis in Cultured Retinal Pigment Epithelial Cells Is Associated with Elevated Levels of Hydrogen Peroxide and Inflammatory Proteins

Sericin-Induced Melanogenesis in Cultured Retinal Pigment Epithelial Cells Is Associated with Elevated Levels of Hydrogen Peroxide and Inflammatory Proteins

We previously demonstrated that the silk protein sericin promotes pigmentation of retinal pigment epithelium (RPE) by activating the NF-κB pathway. Among numerous agents, NF-κB can be activated by hydrogen peroxide. In the present study, we explored possible associations between reactive oxygen spec...

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Bibliographic Details
Main Authors: Ayyad Zartasht Khan, Catherine Joan Jackson, Tor Paaske Utheim, Sjur Reppe, Dipak Sapkota, Ole Kristoffer Olstad, Bernd Thiede, Jon Roger Eidet
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Molecules
Subjects:
sericin
melanogenesis
superoxide dismutase
inflammation
retinal pigment epithelium
hydrogen peroxide
Online Access:https://www.mdpi.com/1420-3049/25/19/4395

Internet

https://www.mdpi.com/1420-3049/25/19/4395

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