Prenatal Endotoxin Exposure Induces Fetal and Neonatal Renal Inflammation via Innate and Th1 Immune Activation in Preterm Pigs

Prenatal Endotoxin Exposure Induces Fetal and Neonatal Renal Inflammation via Innate and Th1 Immune Activation in Preterm Pigs

Chorioamnionitis (CA) predisposes to preterm birth and affects the fetal mucosal surfaces (i.e., gut, lungs, and skin) via intra-amniotic (IA) inflammation, thereby accentuating the proinflammatory status in newborn preterm infants. It is not known if CA may affect more distant organs, such as the k...

Full description

Bibliographic Details
Main Authors: Tik Muk, Ping-Ping Jiang, Allan Stensballe, Kerstin Skovgaard, Per Torp Sangild, Duc Ninh Nguyen
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Immunology
Subjects:
intrauterine bacterial infection
chorioamnionitis
plasma proteomics
renal inflammation
acute kidney injury
immune activation
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.565484/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.565484/full

Similar Items