The interplay of circulating tumor DNA and chromatin modification, therapeutic resistance, and metastasis

Abstract Peripheral circulating free DNA (cfDNA) is DNA that is detected in plasma or serum fluid with a cell-free status. For cancer patients, cfDNA not only originates from apoptotic cells but also from necrotic tumor cells and disseminated tumor cells that have escaped into the blood during epith...

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Main Authors:	Lei Zhang, Yiyi Liang, Shifu Li, Fanyuan Zeng, Yongan Meng, Ziwei Chen, Shuang Liu, Yongguang Tao, Fenglei Yu
Format:	Article
Language:	English
Published:	BMC 2019-03-01
Series:	Molecular Cancer
Subjects:	ctDNA Chromatin modification Therapeutic resistance Metastasis Tumor heterogeneity
Online Access:	http://link.springer.com/article/10.1186/s12943-019-0989-z

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spelling	doaj-acdc390140d1491a907b6ce085808fcb2020-11-25T01:46:37ZengBMCMolecular Cancer1476-45982019-03-0118112010.1186/s12943-019-0989-zThe interplay of circulating tumor DNA and chromatin modification, therapeutic resistance, and metastasisLei Zhang0Yiyi Liang1Shifu Li2Fanyuan Zeng3Yongan Meng4Ziwei Chen5Shuang Liu6Yongguang Tao7Fenglei Yu8Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Department of Pathology, Xiangya Hospital, Central South UniversityKey Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Department of Pathology, Xiangya Hospital, Central South UniversityKey Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Department of Pathology, Xiangya Hospital, Central South UniversityKey Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Department of Pathology, Xiangya Hospital, Central South UniversityKey Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Department of Pathology, Xiangya Hospital, Central South UniversityKey Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Department of Pathology, Xiangya Hospital, Central South UniversityDepartment of Oncology, Institute of Medical Sciences, Xiangya Hospital, Central South UniversityKey Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Department of Pathology, Xiangya Hospital, Central South UniversityDepartment of Thoracic Surgery, Second Xiangya Hospital, Central South UniversityAbstract Peripheral circulating free DNA (cfDNA) is DNA that is detected in plasma or serum fluid with a cell-free status. For cancer patients, cfDNA not only originates from apoptotic cells but also from necrotic tumor cells and disseminated tumor cells that have escaped into the blood during epithelial-mesenchymal transition. Additionally, cfDNA derived from tumors, also known as circulating tumor DNA (ctDNA), carries tumor-associated genetic and epigenetic changes in cancer patients, which makes ctDNA a potential biomarker for the early diagnosis of tumors, monitory and therapeutic evaluations, and prognostic assessments, among others, for various kinds of cancer. Moreover, analyses of cfDNA chromatin modifications can reflect the heterogeneity of tumors and have potential for predicting tumor drug resistance.http://link.springer.com/article/10.1186/s12943-019-0989-zctDNAChromatin modificationTherapeutic resistanceMetastasisTumor heterogeneity
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Lei Zhang Yiyi Liang Shifu Li Fanyuan Zeng Yongan Meng Ziwei Chen Shuang Liu Yongguang Tao Fenglei Yu
spellingShingle	Lei Zhang Yiyi Liang Shifu Li Fanyuan Zeng Yongan Meng Ziwei Chen Shuang Liu Yongguang Tao Fenglei Yu The interplay of circulating tumor DNA and chromatin modification, therapeutic resistance, and metastasis Molecular Cancer ctDNA Chromatin modification Therapeutic resistance Metastasis Tumor heterogeneity
author_facet	Lei Zhang Yiyi Liang Shifu Li Fanyuan Zeng Yongan Meng Ziwei Chen Shuang Liu Yongguang Tao Fenglei Yu
author_sort	Lei Zhang
title	The interplay of circulating tumor DNA and chromatin modification, therapeutic resistance, and metastasis
title_short	The interplay of circulating tumor DNA and chromatin modification, therapeutic resistance, and metastasis
title_full	The interplay of circulating tumor DNA and chromatin modification, therapeutic resistance, and metastasis
title_fullStr	The interplay of circulating tumor DNA and chromatin modification, therapeutic resistance, and metastasis
title_full_unstemmed	The interplay of circulating tumor DNA and chromatin modification, therapeutic resistance, and metastasis
title_sort	interplay of circulating tumor dna and chromatin modification, therapeutic resistance, and metastasis
publisher	BMC
series	Molecular Cancer
issn	1476-4598
publishDate	2019-03-01
description	Abstract Peripheral circulating free DNA (cfDNA) is DNA that is detected in plasma or serum fluid with a cell-free status. For cancer patients, cfDNA not only originates from apoptotic cells but also from necrotic tumor cells and disseminated tumor cells that have escaped into the blood during epithelial-mesenchymal transition. Additionally, cfDNA derived from tumors, also known as circulating tumor DNA (ctDNA), carries tumor-associated genetic and epigenetic changes in cancer patients, which makes ctDNA a potential biomarker for the early diagnosis of tumors, monitory and therapeutic evaluations, and prognostic assessments, among others, for various kinds of cancer. Moreover, analyses of cfDNA chromatin modifications can reflect the heterogeneity of tumors and have potential for predicting tumor drug resistance.
topic	ctDNA Chromatin modification Therapeutic resistance Metastasis Tumor heterogeneity
url	http://link.springer.com/article/10.1186/s12943-019-0989-z
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The interplay of circulating tumor DNA and chromatin modification, therapeutic resistance, and metastasis

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