The interplay of circulating tumor DNA and chromatin modification, therapeutic resistance, and metastasis

The interplay of circulating tumor DNA and chromatin modification, therapeutic resistance, and metastasis

Abstract Peripheral circulating free DNA (cfDNA) is DNA that is detected in plasma or serum fluid with a cell-free status. For cancer patients, cfDNA not only originates from apoptotic cells but also from necrotic tumor cells and disseminated tumor cells that have escaped into the blood during epith...

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Bibliographic Details
Main Authors: Lei Zhang, Yiyi Liang, Shifu Li, Fanyuan Zeng, Yongan Meng, Ziwei Chen, Shuang Liu, Yongguang Tao, Fenglei Yu
Format: Article
Language:English
Published: BMC 2019-03-01
Series:Molecular Cancer
Subjects:
ctDNA
Chromatin modification
Therapeutic resistance
Metastasis
Tumor heterogeneity
Online Access:http://link.springer.com/article/10.1186/s12943-019-0989-z

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http://link.springer.com/article/10.1186/s12943-019-0989-z

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