N-glycosylation Triggers a Dual Selection Pressure in Eukaryotic Secretory Proteins

N-glycosylation Triggers a Dual Selection Pressure in Eukaryotic Secretory Proteins

Abstract Nearly one third of the eukaryotic proteome traverses the secretory pathway and most of these proteins are N-glycosylated in the lumen of the endoplasmic reticulum. N-glycans fulfill multiple structural and biological functions, and are crucial for productive folding of many glycoproteins....

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Main Authors: Máximo Lopez Medus, Gabriela E. Gomez, Lucía F. Zacchi, Paula M. Couto, Carlos A. Labriola, María S. Labanda, Rodrigo Corti Bielsa, Eugenia M. Clérico, Benjamin L. Schulz, Julio J. Caramelo
Format: Article
Language:English
Published: Nature Publishing Group 2017-08-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-09173-6

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https://doi.org/10.1038/s41598-017-09173-6

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