Identification of an annonaceous acetogenin mimetic, AA005, as an AMPK activator and autophagy inducer in colon cancer cells.

Identification of an annonaceous acetogenin mimetic, AA005, as an AMPK activator and autophagy inducer in colon cancer cells.

Annonaceous acetogenins, a large family of naturally occurring polyketides isolated from various species of the plant genus Annonaceae, have been found to exhibit significant cytotoxicity against a variety of cancer cells. Previous studies showed that these compounds could act on the mitochondria co...

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Bibliographic Details
Main Authors: Yong-Qiang Liu, Xin Cheng, Liang-Xia Guo, Chan Mao, Yi-Jie Chen, Hai-Xia Liu, Qi-Cai Xiao, Sheng Jiang, Zhu-Jun Yao, Guang-Biao Zhou
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3466238?pdf=render

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http://europepmc.org/articles/PMC3466238?pdf=render

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