A microRNA negative feedback loop downregulates vesicle transport and inhibits fear memory

A microRNA negative feedback loop downregulates vesicle transport and inhibits fear memory

The SNARE-mediated vesicular transport pathway plays major roles in synaptic remodeling associated with formation of long-term memories, but the mechanisms that regulate this pathway during memory acquisition are not fully understood. Here we identify miRNAs that are up-regulated in the rodent hippo...

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Bibliographic Details
Main Authors: Rebecca S Mathew, Antonis Tatarakis, Andrii Rudenko, Erin M Johnson-Venkatesh, Yawei J Yang, Elisabeth A Murphy, Travis P Todd, Scott T Schepers, Nertila Siuti, Anthony J Martorell, William A Falls, Sayamwong E Hammack, Christopher A Walsh, Li-Huei Tsai, Hisashi Umemori, Mark E Bouton, Danesh Moazed
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-12-01
Series:eLife
Subjects:
learning
memory
synaptic plasticity
miRNA
hippocampus
negative feed back loop
Online Access:https://elifesciences.org/articles/22467

Internet

https://elifesciences.org/articles/22467

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