TLR-3 Stimulation Skews M2 Macrophages to M1 Through IFN-αβ Signaling and Restricts Tumor Progression

TLR-3 Stimulation Skews M2 Macrophages to M1 Through IFN-αβ Signaling and Restricts Tumor Progression

During tumor progression, macrophages shift their protective M1-phenotype to pro-tumorigenic M2-subtype. Therefore, conversion of M2 to M1 phenotype may be a potential therapeutic intervention. TLRs are important pathogen recognition receptors expressed by cells of the immune system. Recently, a cru...

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Bibliographic Details
Main Authors: Aurobind Vidyarthi, Nargis Khan, Tapan Agnihotri, Shikha Negi, Deepjyoti K. Das, Mohammad Aqdas, Deepyan Chatterjee, Oscar R. Colegio, Manoj K. Tewari, Javed N. Agrewala
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Immunology
Subjects:
tumor-associated macrophages
IFN-αβ
TLR-3
tumor microenvironment
Tim-3
CD206
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01650/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.01650/full

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