Calculus Bovis Sativus Improves Bile Acid Homeostasis via Farnesoid X Receptor-Mediated Signaling in Rats With Estrogen-Induced Cholestasis

Calculus Bovis Sativus Improves Bile Acid Homeostasis via Farnesoid X Receptor-Mediated Signaling in Rats With Estrogen-Induced Cholestasis

Cholestatic diseases are characterized by toxic bile acid (BA) accumulation, and abnormal BA composition, which subsequently lead to liver injury. Biochemical synthetic Calculus Bovis Sativus (CBS) is derived from natural Calculus Bovis, a traditional Chinese medicine, which has been used to treat h...

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Bibliographic Details
Main Authors: Dong Xiang, Jinyu Yang, Yanan Liu, Wenxi He, Si Zhang, Xiping Li, Chenliang Zhang, Dong Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-02-01
Series:Frontiers in Pharmacology
Subjects:
Calculus Bovis Sativus
cholestasis
FXR
17α-ethinylestradiol
bile acid
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.00048/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2019.00048/full

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