Evaluation of Signature Erosion in Ebola Virus Due to Genomic Drift and Its Impact on the Performance of Diagnostic Assays

Evaluation of Signature Erosion in Ebola Virus Due to Genomic Drift and Its Impact on the Performance of Diagnostic Assays

Genome sequence analyses of the 2014 Ebola Virus (EBOV) isolates revealed a potential problem with the diagnostic assays currently in use; i.e., drifting genomic profiles of the virus may affect the sensitivity or even produce false-negative results. We evaluated signature erosion in ebolavirus mole...

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Bibliographic Details
Main Authors: Shanmuga Sozhamannan, Mitchell Y. Holland, Adrienne T. Hall, Daniel A. Negrón, Mychal Ivancich, Jeffrey W. Koehler, Timothy D. Minogue, Catherine E. Campbell, Walter J. Berger, George W. Christopher, Bruce G. Goodwin, Michael A. Smith
Format: Article
Language:English
Published: MDPI AG 2015-06-01
Series:Viruses
Subjects:
EBOV
Western African outbreak
WGS
qRT-PCR
signature erosion
PSET
BioVelocity
Online Access:http://www.mdpi.com/1999-4915/7/6/2763

Internet

http://www.mdpi.com/1999-4915/7/6/2763

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