Mitochondria-Associated Degradation Pathway (MAD) Function beyond the Outer Membrane

Mitochondria-Associated Degradation Pathway (MAD) Function beyond the Outer Membrane

Summary: The mitochondria-associated degradation pathway (MAD) mediates ubiquitination and degradation of mitochondrial outer membrane (MOM) proteins by the proteasome. We find that the MAD, but not other quality-control pathways including macroautophagy, mitophagy, or mitochondrial chaperones and p...

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Bibliographic Details
Main Authors: Pin-Chao Liao, Dana M. Alessi Wolken, Edith Serrano, Pallavi Srivastava, Liza A. Pon
Format: Article
Language:English
Published: Elsevier 2020-07-01
Series:Cell Reports
Subjects:
mitochondrial quality control
oxidative stress
reactive oxygen species
proteostasis
paraquat
ubiquitin
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720308834

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http://www.sciencedirect.com/science/article/pii/S2211124720308834

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