Sildenafil Attenuates Hepatocellular Injury after Liver Ischemia Reperfusion in Rats: A Preliminary Study

We evaluated the role of sildenafil in a rat liver ischemia-reperfusion model. Forty male rats were randomly allocated in four groups. The sham group underwent midline laparotomy only. In the sildenafil group, sildenafil was administered intraperitoneally 60 minutes before sham laparotomy. In the is...

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Main Authors: Spyridon Savvanis, Constantinos Nastos, Marios-Konstantinos Tasoulis, Nikolaos Papoutsidakis, Maria Demonakou, Iosifina Karmaniolou, Nikolaos Arkadopoulos, Vassilios Smyrniotis, Kassiani Theodoraki
Format: Article
Language:English
Published: Hindawi Limited 2014-01-01
Series:Oxidative Medicine and Cellular Longevity
Online Access:http://dx.doi.org/10.1155/2014/161942