Intestinal SIRT3 overexpression in mice improves whole body glucose homeostasis independent of body weight

Intestinal SIRT3 overexpression in mice improves whole body glucose homeostasis independent of body weight

Objective: Intestinal metabolism might play a greater role in regulating whole body metabolism than previously believed. We aimed to enhance enterocyte metabolism in mice and investigate if it plays a role in diet-induced obesity (DIO) and its comorbidities. Methods: Using the cre-loxP system, we ov...

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Bibliographic Details
Main Authors: Deepti Ramachandran, Rosmarie Clara, Shahana Fedele, Junmin Hu, Endre Lackzo, Jing-Yi Huang, Eric Verdin, Wolfgang Langhans, Abdelhak Mansouri
Format: Article
Language:English
Published: Elsevier 2017-10-01
Series:Molecular Metabolism
Subjects:
Insulin resistance
Oxidative metabolism
Ketone bodies
Enterocytes
Gut
Sirtuins
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877817304386

Internet

http://www.sciencedirect.com/science/article/pii/S2212877817304386

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