Deletion of the Virion Host Shut-off Gene Enhances Neuronal-Selective Transgene Expression from an HSV Vector Lacking Functional IE Genes

Deletion of the Virion Host Shut-off Gene Enhances Neuronal-Selective Transgene Expression from an HSV Vector Lacking Functional IE Genes

The ability of herpes simplex virus (HSV) to establish lifelong latency in neurons suggests that HSV-derived vectors hold promise for gene delivery to the nervous system. However, vector toxicity and transgene silencing have created significant barriers to vector applications to the brain. Recently,...

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Bibliographic Details
Main Authors: Yoshitaka Miyagawa, Gianluca Verlengia, Bonnie Reinhart, Fang Han, Hiroaki Uchida, Silvia Zucchini, William F. Goins, Michele Simonato, Justus B. Cohen, Joseph C. Glorioso
Format: Article
Language:English
Published: Elsevier 2017-09-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
HSV
gene therapy
CNS
virion host shutoff gene
ICP4
ICP0
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050117300761

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http://www.sciencedirect.com/science/article/pii/S2329050117300761

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