Pharmacodynamic Evaluation of Dosing, Bacterial Kill, and Resistance Suppression for Zoliflodacin Against Neisseria gonorrhoeae in a Dynamic Hollow Fiber Infection Model

Pharmacodynamic Evaluation of Dosing, Bacterial Kill, and Resistance Suppression for Zoliflodacin Against Neisseria gonorrhoeae in a Dynamic Hollow Fiber Infection Model

Antimicrobial resistance in Neisseria gonorrhoeae is threatening the treatment and control of gonorrhea globally, and new treatment options are imperative. Utilizing our dynamic in vitro hollow fiber infection model (HFIM), we examined the pharmacodynamics of the first-in-class spiropyrimidinetrione...

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Bibliographic Details
Main Authors: Susanne Jacobsson, Daniel Golparian, Joakim Oxelbark, Emilie Alirol, Francois Franceschi, Tomas N. Gustafsson, David Brown, Arnold Louie, George Drusano, Magnus Unemo
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Pharmacology
Subjects:
Neisseria gonorrhoeae
hollow fiber infection model
zoliflodacin
pharmacodynamics
antimicrobial treatment
pharmacokinetics
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.682135/full

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https://www.frontiersin.org/articles/10.3389/fphar.2021.682135/full

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