Ginsenoside Rd promotes glutamate clearance by up-regulating glial glutamate transporter GLT-1 via PI3K/AKT and ERK 1/2 pathways

Ginsenoside Rd promotes glutamate clearance by up-regulating glial glutamate transporter GLT-1 via PI3K/AKT and ERK 1/2 pathways

Ginsenoside Rd (Rd), one of the main active ingredients in Panax ginseng, has been showed to protect against ischemic cerebral damage both in vitro and in vivo. However, the underlying mechanism of Rd is largely unknown. Excessive extracellular glutamate causes excitatory toxicity, leading to cell d...

Full description

Bibliographic Details
Main Authors: Zhang eXiao, shi eming, Magnar eBjørås, wang ewei, zhang eguangyun, han ejunliang, liu ezhirong, zhang eyunxia, wang ebing, chen ejing, zhu eyi, xiong elize, Zhao eGang
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-12-01
Series:Frontiers in Pharmacology
Subjects:
Stroke
Glutamate
Neuroprotection
astrocyte
PI3K/AKT
ginseng
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2013.00152/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphar.2013.00152/full

Similar Items