Source and Purity of Dengue-Viral Preparations Impact Requirement for Enhancing Antibody to Induce Elevated IL-1β Secretion: A Primary Human Monocyte Model.

Source and Purity of Dengue-Viral Preparations Impact Requirement for Enhancing Antibody to Induce Elevated IL-1β Secretion: A Primary Human Monocyte Model.

Dengue virus is a major global health threat and can lead to life-threatening hemorrhagic complications due to immune activation and cytokine production. Cross-reactive antibodies to an earlier dengue virus infection are a recognized risk factor for severe disease. These antibodies bind heterologous...

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Bibliographic Details
Main Authors: Justin B Callaway, Scott A Smith, Douglas G Widman, Karen P McKinnon, Frank Scholle, Gregory D Sempowski, Dirk P Dittmer, James E Crowe, Aravinda M de Silva, Jenny P-Y Ting
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4547738?pdf=render

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http://europepmc.org/articles/PMC4547738?pdf=render

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