Human Macrophages Escape Inhibition of Major Histocompatibility Complex-Dependent Antigen Presentation by Cytomegalovirus and Drive Proliferation and Activation of Memory CD4+ and CD8+ T Cells

Human Macrophages Escape Inhibition of Major Histocompatibility Complex-Dependent Antigen Presentation by Cytomegalovirus and Drive Proliferation and Activation of Memory CD4+ and CD8+ T Cells

Human cytomegalovirus (HCMV) persistently infects 40–90% of the human population but in the face of a normal immune system, viral spread and dissemination are efficiently controlled thus preventing clinically signs and disease. HCMV-infected hosts produce a remarkably large amount of HCMV-specific C...

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Bibliographic Details
Main Authors: Giada Frascaroli, Carina Lecher, Stefania Varani, Corinna Setz, Johannes van der Merwe, Wolfram Brune, Thomas Mertens
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-05-01
Series:Frontiers in Immunology
Subjects:
human cytomegalovirus
macrophages
US2-11 immune evasive genes
major histocompatibility complex molecules
T-cell proliferation
T-cell activation
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01129/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.01129/full

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