Effects of naringenin on renal expression of organic cation transporter 1 and 2 proteins and metformin disposition in diabetic rats

Effects of naringenin on renal expression of organic cation transporter 1 and 2 proteins and metformin disposition in diabetic rats

Modulation of metformin transporters could affect its pharmacokinetics/pharmacodynamics. The effects of naringenin on the renal tubular Organic Cation Transporter 1 (OCT1) and 2 (OCT2) protein expressions and subsequently the metformin clearance in diabetic rats are hereby investigated. Male Sprague...

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Bibliographic Details
Main Authors: Edith Pascale Mofo Mato, M. Faadiel Essop, Peter Mark Oroma Owira
Format: Article
Language:English
Published: Elsevier 2019-08-01
Series:Journal of Functional Foods
Subjects:
Renal tubular secretion
Metformin
Naringenin
Diabetes
OCT1
OCT2
Online Access:http://www.sciencedirect.com/science/article/pii/S1756464619302762

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http://www.sciencedirect.com/science/article/pii/S1756464619302762

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