Structural basis for the recognition of cellular mRNA export factor REF by herpes viral proteins HSV-1 ICP27 and HVS ORF57.

Structural basis for the recognition of cellular mRNA export factor REF by herpes viral proteins HSV-1 ICP27 and HVS ORF57.

The herpesvirus proteins HSV-1 ICP27 and HVS ORF57 promote viral mRNA export by utilizing the cellular mRNA export machinery. This function is triggered by binding to proteins of the transcription-export (TREX) complex, in particular to REF/Aly which directs viral mRNA to the TAP/NFX1 pathway and, s...

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Bibliographic Details
Main Authors: Richard B Tunnicliffe, Guillaume M Hautbergue, Priti Kalra, Brian R Jackson, Adrian Whitehouse, Stuart A Wilson, Alexander P Golovanov
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC3017119?pdf=render

Internet

http://europepmc.org/articles/PMC3017119?pdf=render

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