Intracellular Delivery of Short Interfering RNA in Rat Organ of Corti Using a Cell-penetrating Peptide PepFect6

Intracellular Delivery of Short Interfering RNA in Rat Organ of Corti Using a Cell-penetrating Peptide PepFect6

RNA interference (RNAi) using short interfering RNA (siRNA) is an attractive therapeutic approach for treatment of dominant-negative mutations. Some rare missense dominant-negative mutations lead to congenital-hearing impairments. A variety of viral vectors have been tested with variable efficacy fo...

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Bibliographic Details
Main Authors: Suvarna Dash-Wagh, Stefan Jacob, Staffan Lindberg, Anders Fridberger, Ülo Langel, Mats Ulfendahl
Format: Article
Language:English
Published: Elsevier 2012-01-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
cell-penetrating peptide (CPP)
cochlea
connexin
FRAP
gap junctions
gene therapy
inner ear
nanoparticles
siRNA
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253116301160

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http://www.sciencedirect.com/science/article/pii/S2162253116301160

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