Iron-dependent apoptosis causes embryotoxicity in inflamed and obese pregnancy

Iron-dependent apoptosis causes embryotoxicity in inflamed and obese pregnancy

Iron is essential during pregnancy for embryo and placental development and maternal health. However, in this study using mouse models, the authors demonstrate that excess maternal iron causes adverse embryo outcomes in pregnancies with underlying systemic inflammation.

Bibliographic Details
Main Authors: Allison L. Fisher, Veena Sangkhae, Kamila Balušíková, Nicolaos J. Palaskas, Tomas Ganz, Elizabeta Nemeth
Format: Article
Language:English
Published: Nature Publishing Group 2021-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-24333-z
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spelling doaj-ac4d64ab15ae4a03b59b5d134970dd442021-07-04T11:45:44ZengNature Publishing GroupNature Communications2041-17232021-06-0112111610.1038/s41467-021-24333-zIron-dependent apoptosis causes embryotoxicity in inflamed and obese pregnancyAllison L. Fisher0Veena Sangkhae1Kamila Balušíková2Nicolaos J. Palaskas3Tomas Ganz4Elizabeta Nemeth5Molecular, Cellular & Integrative Physiology Graduate Program, University of California, Los AngelesCenter for Iron Disorders, David Geffen School of Medicine, University of California, Los AngelesDepartment of Biochemistry, Cell and Molecular Biology & Center for Research of Diabetes, Metabolism and Nutrition, Third Faculty of Medicine, Charles UniversityCenter for Iron Disorders, David Geffen School of Medicine, University of California, Los AngelesCenter for Iron Disorders, David Geffen School of Medicine, University of California, Los AngelesCenter for Iron Disorders, David Geffen School of Medicine, University of California, Los AngelesIron is essential during pregnancy for embryo and placental development and maternal health. However, in this study using mouse models, the authors demonstrate that excess maternal iron causes adverse embryo outcomes in pregnancies with underlying systemic inflammation.https://doi.org/10.1038/s41467-021-24333-z
collection DOAJ
language English
format Article
sources DOAJ
author Allison L. Fisher
Veena Sangkhae
Kamila Balušíková
Nicolaos J. Palaskas
Tomas Ganz
Elizabeta Nemeth
spellingShingle Allison L. Fisher
Veena Sangkhae
Kamila Balušíková
Nicolaos J. Palaskas
Tomas Ganz
Elizabeta Nemeth
Iron-dependent apoptosis causes embryotoxicity in inflamed and obese pregnancy
Nature Communications
author_facet Allison L. Fisher
Veena Sangkhae
Kamila Balušíková
Nicolaos J. Palaskas
Tomas Ganz
Elizabeta Nemeth
author_sort Allison L. Fisher
title Iron-dependent apoptosis causes embryotoxicity in inflamed and obese pregnancy
title_short Iron-dependent apoptosis causes embryotoxicity in inflamed and obese pregnancy
title_full Iron-dependent apoptosis causes embryotoxicity in inflamed and obese pregnancy
title_fullStr Iron-dependent apoptosis causes embryotoxicity in inflamed and obese pregnancy
title_full_unstemmed Iron-dependent apoptosis causes embryotoxicity in inflamed and obese pregnancy
title_sort iron-dependent apoptosis causes embryotoxicity in inflamed and obese pregnancy
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2021-06-01
description Iron is essential during pregnancy for embryo and placental development and maternal health. However, in this study using mouse models, the authors demonstrate that excess maternal iron causes adverse embryo outcomes in pregnancies with underlying systemic inflammation.
url https://doi.org/10.1038/s41467-021-24333-z
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AT veenasangkhae irondependentapoptosiscausesembryotoxicityininflamedandobesepregnancy
AT kamilabalusikova irondependentapoptosiscausesembryotoxicityininflamedandobesepregnancy
AT nicolaosjpalaskas irondependentapoptosiscausesembryotoxicityininflamedandobesepregnancy
AT tomasganz irondependentapoptosiscausesembryotoxicityininflamedandobesepregnancy
AT elizabetanemeth irondependentapoptosiscausesembryotoxicityininflamedandobesepregnancy
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