SAM homeostasis is regulated by CFIm-mediated splicing of MAT2A

SAM homeostasis is regulated by CFIm-mediated splicing of MAT2A

S-adenosylmethionine (SAM) is the methyl donor for nearly all cellular methylation events. Cells regulate intracellular SAM levels through intron detention of MAT2A, the only SAM synthetase expressed in most cells. The N6-adenosine methyltransferase METTL16 promotes splicing of the MAT2A detained in...

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Bibliographic Details
Main Authors: Anna M Scarborough, Juliana N Flaherty, Olga V Hunter, Kuanqing Liu, Ashwani Kumar, Chao Xing, Benjamin P Tu, Nicholas K Conrad
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-05-01
Series:eLife
Subjects:
sam homeostasis
intron retention
alternative splicing
METTL16
nudt21 cfim25
MAT2A
Online Access:https://elifesciences.org/articles/64930

Internet

https://elifesciences.org/articles/64930

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