ERdj5 in Innate Immune Cells Is a Crucial Factor for the Mucosal Adjuvanticity of Cholera Toxin

ERdj5 in Innate Immune Cells Is a Crucial Factor for the Mucosal Adjuvanticity of Cholera Toxin

Cholera toxin (CT) is one of most strong mucosal adjuvants, but it cannot be clinically used owing to its toxicity. The cytosolic A1 subunit of CT (CTA1) is the molecule responsible for its immunostimulatory activity, which increases the concentration of cyclic AMP and causes the induction of pro-in...

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Bibliographic Details
Main Authors: Mee-Sun Kim, Eun-Je Yi, Young-In Kim, So Hee Kim, Yi-Sook Jung, Seong-Ryeol Kim, Takao Iwawaki, Hyun-Jeong Ko, Sun-Young Chang
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-06-01
Series:Frontiers in Immunology
Subjects:
cholera toxin (CT)
ERdj5
mucosal adjuvant
ER stress
dendrtic cells
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01249/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.01249/full

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