SSADH Variants Increase Susceptibility of U87 Cells to Mitochondrial Pro-Oxidant Insult

Succinate semialdehyde dehydrogenase (SSADH) is a mitochondrial enzyme, encoded by <i>ALDH5A1</i>, mainly involved in γ-aminobutyric acid (GABA) catabolism and energy supply of neuronal cells, possibly contributing to antioxidant defense. This study aimed to further investigate the antio...

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Bibliographic Details
Main Authors: Giovanna Menduti, Alessandra Vitaliti, Concetta Rosa Capo, Daniele Lettieri-Barbato, Katia Aquilano, Patrizia Malaspina, Luisa Rossi
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:International Journal of Molecular Sciences
Subjects:
SSA
Online Access:https://www.mdpi.com/1422-0067/21/12/4374