Comprehensive antigenic map of a cleaved soluble HIV-1 envelope trimer.

Comprehensive antigenic map of a cleaved soluble HIV-1 envelope trimer.

The trimeric envelope (Env) spike is the focus of vaccine design efforts aimed at generating broadly neutralizing antibodies (bNAbs) to protect against HIV-1 infection. Three recent developments have facilitated a thorough investigation of the antigenic structure of the Env trimer: 1) the isolation...

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Bibliographic Details
Main Authors: Ronald Derking, Gabriel Ozorowski, Kwinten Sliepen, Anila Yasmeen, Albert Cupo, Jonathan L Torres, Jean-Philippe Julien, Jeong Hyun Lee, Thijs van Montfort, Steven W de Taeye, Mark Connors, Dennis R Burton, Ian A Wilson, Per-Johan Klasse, Andrew B Ward, John P Moore, Rogier W Sanders
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-03-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC4373910?pdf=render

Internet

http://europepmc.org/articles/PMC4373910?pdf=render

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