CD4+ T Cells Recognize Conserved Influenza A Epitopes through Shared Patterns of V-Gene Usage and Complementary Biochemical Features

CD4+ T Cells Recognize Conserved Influenza A Epitopes through Shared Patterns of V-Gene Usage and Complementary Biochemical Features

Summary: T cell recognition of peptides presented by human leukocyte antigens (HLAs) is mediated by the highly variable T cell receptor (TCR). Despite this built-in TCR variability, individuals can mount immune responses against viral epitopes by using identical or highly related TCRs expressed on C...

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Bibliographic Details
Main Authors: Alexander Greenshields-Watson, Meriem Attaf, Bruce J. MacLachlan, Thomas Whalley, Cristina Rius, Aaron Wall, Angharad Lloyd, Hywel Hughes, Kathryn E. Strange, Georgina H. Mason, Andrea J. Schauenburg, Sarah L. Hulin-Curtis, James Geary, Yuan Chen, Sarah N. Lauder, Kathryn Smart, Dhanasekaran Vijaykrishna, Miguel L. Grau, Mikhail Shugay, Robert Andrews, Garry Dolton, Pierre J. Rizkallah, Awen M. Gallimore, Andrew K. Sewell, Andrew J. Godkin, David K. Cole
Format: Article
Language:English
Published: Elsevier 2020-07-01
Series:Cell Reports
Subjects:
influenza
CD4 T cells
HLA class II
peptide epitopes
pHLA mutlimer
T cell receptor
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720308664

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http://www.sciencedirect.com/science/article/pii/S2211124720308664

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