Stroma-Derived Connective Tissue Growth Factor Maintains Cell Cycle Progression and Repopulation Activity of Hematopoietic Stem Cells In Vitro

Stroma-Derived Connective Tissue Growth Factor Maintains Cell Cycle Progression and Repopulation Activity of Hematopoietic Stem Cells In Vitro

Hematopoietic stem cells (HSCs) are preserved in co-cultures with UG26-1B6 stromal cells or their conditioned medium. We performed a genome-wide study of gene expression changes of UG26-1B6 stromal cells in contact with Lineage− SCA-1+ KIT+ (LSK) cells. This analysis identified connective tissue gro...

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Bibliographic Details
Main Authors: Rouzanna Istvánffy, Baiba Vilne, Christina Schreck, Franziska Ruf, Charlotta Pagel, Sandra Grziwok, Lynette Henkel, Olivia Prazeres da Costa, Johannes Berndt, Volker Stümpflen, Katharina S. Götze, Matthias Schiemann, Christian Peschel, Hans-Werner Mewes, Robert A.J. Oostendorp
Format: Article
Language:English
Published: Elsevier 2015-11-01
Series:Stem Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2213671115002805

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http://www.sciencedirect.com/science/article/pii/S2213671115002805

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