Leptin deficiency reverses high metabolic state and weight loss without affecting central pathology in the R6/2 mouse model of Huntington's disease

Leptin deficiency reverses high metabolic state and weight loss without affecting central pathology in the R6/2 mouse model of Huntington's disease

Body weight has been shown to be a predictor of clinical progression in Huntington's disease (HD). Alongside widespread neuronal pathology, both HD patients and the R6/2 mouse model of HD exhibit weight loss and increased energy expenditure, providing a rationale for targeting whole-body energy...

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Bibliographic Details
Main Authors: Marie Sjögren, Rana Soylu-Kucharz, Unali Dandunna, Tiberiu Loredan Stan, Michele Cavalera, Åsa Sandelius, Henrik Zetterberg, Maria Björkqvist
Format: Article
Language:English
Published: Elsevier 2019-12-01
Series:Neurobiology of Disease
Subjects:
Leptin-deficiency
Energy metabolism
Oxygen consumption
Adipose tissue
Huntington's disease
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996119302281

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http://www.sciencedirect.com/science/article/pii/S0969996119302281

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