A novel thymidylate synthase from the Vibrionales, Alteromonadales, Aeromonadales, and Pasteurellales (VAAP) clade with altered nucleotide and folate binding sites

A novel thymidylate synthase from the Vibrionales, Alteromonadales, Aeromonadales, and Pasteurellales (VAAP) clade with altered nucleotide and folate binding sites

Thymidylate synthase (TS, E.C. 2.1.1.45) is a crucial enzyme for de novo deoxythymidine monophosphate (dTMP) biosynthesis. The gene for this enzyme is thyA, which encodes the folate-dependent TS that converts deoxyuridine monophosphate group (dUMP) into (dTMP) using the cofactor 5,10-methylenetetrah...

Full description

Bibliographic Details
Main Authors: Alonso A. Lopez-Zavala, Eduardo Guevara-Hernandez, Luz H. Vazquez-Lujan, Arturo Sanchez-Paz, Karina D. Garcia-Orozco, Carmen A. Contreras-Vergara, Gamaliel Lopez-Leal, Aldo A. Arvizu-Flores, Adrian Ochoa-Leyva, Rogerio R. Sotelo-Mundo
Format: Article
Language:English
Published: PeerJ Inc. 2018-06-01
Series:PeerJ
Subjects:
Vibrio parahaemolyticus
Trimethoprim
Gammaproteobacteria
Alteromonadales
Enzyme
Aeromonadales
Online Access:https://peerj.com/articles/5023.pdf

Internet

https://peerj.com/articles/5023.pdf

Similar Items