Assessing diagnostic tests: how to correct for the combined effects of interpretation and reference standard.

We describe a general solution to the problem of determining diagnostic accuracy without the use of a perfect reference standard and in the presence of interpreter variability. The accuracy of a diagnostic test is typically determined by comparing its outcomes with those of an established reference...

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Bibliographic Details
Main Authors: Ahmet Omurtag, Andre A Fenton
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3530612?pdf=render