Synthetically Lethal Interactions of Heme Oxygenase-1 and Fumarate Hydratase Genes

Synthetically Lethal Interactions of Heme Oxygenase-1 and Fumarate Hydratase Genes

Elevated expression of heme oxygenase-1 (HO-1, encoded by <i>HMOX1</i>) is observed in various types of tumors. Hence, it is suggested that HO-1 may serve as a potential target in anticancer therapies. A novel approach to inhibit HO-1 is related to the synthetic lethality of this enzyme...

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Bibliographic Details
Main Authors: Paulina Podkalicka, Olga Mucha, Szczepan Kruczek, Anna Biela, Kalina Andrysiak, Jacek Stępniewski, Maciej Mikulski, Michał Gałęzowski, Kamil Sitarz, Krzysztof Brzózka, Alicja Józkowicz, Józef Dulak, Agnieszka Łoboda
Format: Article
Language:English
Published: MDPI AG 2020-01-01
Series:Biomolecules
Subjects:
heme oxygenase-1
fumarate hydratase
small-molecule inhibitors
synthetic lethality hereditary leiomyomatosis and renal cell carcinoma
Online Access:https://www.mdpi.com/2218-273X/10/1/143

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https://www.mdpi.com/2218-273X/10/1/143

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