Nanoparticle-Based Delivery of RNAi Therapeutics: Progress and Challenges

Nanoparticle-Based Delivery of RNAi Therapeutics: Progress and Challenges

RNA interference (RNAi) is an evolutionarily conserved, endogenous process for post-transcriptional regulation of gene expression. Although RNAi therapeutics have recently progressed through the pipeline toward clinical trials, the application of these as ideal, clinical therapeutics requires the de...

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Bibliographic Details
Main Authors: John C. Burnett, John J. Rossi, Jiehua Zhou, Ka-To Shum
Format: Article
Language:English
Published: MDPI AG 2013-01-01
Series:Pharmaceuticals
Subjects:
small interfering (si)RNA
non-viral vector
multifunctional nanoparticle
targeting delivery
passive and active targeting
Online Access:http://www.mdpi.com/1424-8247/6/1/85

Internet

http://www.mdpi.com/1424-8247/6/1/85

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