Stromal Cell-Derived Factor 1α Mediates Resistance to mTOR-Directed Therapy in Pancreatic Cancer

Stromal Cell-Derived Factor 1α Mediates Resistance to mTOR-Directed Therapy in Pancreatic Cancer

PURPOSE: The factors preventing the translation of preclinical findings supporting the clinical development mTOR-targeted therapy in pancreatic cancer therapy remain undetermined. Stromal cell.derived factor 1α (SDF-1α)-CXCR4 signaling was examined as a representative microenvironmental factor able...

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Bibliographic Details
Main Authors: Colin D. Weekes, Dongweon Song, John Arcaroli, Lora A. Wilson, Belen Rubio-Viqueira, George Cusatis, Elizabeth Garrett-Mayer, Wells A. Messersmith, Robert A. Winn, Manuel Hidalgo
Format: Article
Language:English
Published: Elsevier 2012-08-01
Series:Neoplasia: An International Journal for Oncology Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558612800030

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http://www.sciencedirect.com/science/article/pii/S1476558612800030

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