Computer simulation of the spatial structure of MUC 1 peptides capable of inhibiting apoptosis

Computer simulation of the spatial structure of MUC 1 peptides capable of inhibiting apoptosis

Identification of new effective inhibitors of apoptosis is an important task for drug development for treatment of a number diseases including neurogenerative diseases. Initiation of apoptosis occurs via the formationof macromolecular protein complexes. In these complexes, activation of key enzymes...

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Bibliographic Details
Main Authors: N. V. Ivanisenko, I. N. Lavrik, V. A. Ivanisenko
Format: Article
Language:English
Published: Institute of Cytology and Genetics of Siberian Branch of the Russian Academy of Sciences 2016-01-01
Series:Vavilovskij Žurnal Genetiki i Selekcii
Subjects:
apoptosis
programmed cell death
fa dd
muc1
caspase-8
molecular dynamics
implicit salvation
generalized born model
protein structure prediction
Online Access:https://vavilov.elpub.ru/jour/article/view/491

Internet

https://vavilov.elpub.ru/jour/article/view/491

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