20(S)-ginsenoside Rh2 induces caspase-dependent promyelocytic leukemia-retinoic acid receptor A degradation in NB4 cells via Akt/Bax/caspase9 and TNF-α/caspase8 signaling cascades

20(S)-ginsenoside Rh2 induces caspase-dependent promyelocytic leukemia-retinoic acid receptor A degradation in NB4 cells via Akt/Bax/caspase9 and TNF-α/caspase8 signaling cascades

Background: Acute promyelocytic leukemia (APL) is a hematopoietic malignancy driven by promyelocytic leukemia–retinoic acid receptor A (PML-RARA) fusion gene. The therapeutic drugs currently used to treat APL have adverse effects. 20(S)-ginsenoside Rh2 (GRh2) is an anticancer medicine with high effe...

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Bibliographic Details
Main Authors: Sirui Zhu, Xiaoli Liu, Mei Xue, Yu Li, Danhong Cai, Shijun Wang, Liang Zhang
Format: Article
Language:English
Published: Elsevier 2021-03-01
Series:Journal of Ginseng Research
Subjects:
Acute promyelocytic leukemia
Apoptosis
Caspase
20(S)-ginsenoside Rh2
PML-RARA
Online Access:http://www.sciencedirect.com/science/article/pii/S1226845320300877

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http://www.sciencedirect.com/science/article/pii/S1226845320300877

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