Is dopamine transporter-mediated dopaminergic signaling in the retina a noninvasive biomarker for attention-deficit/ hyperactivity disorder? A study in a novel dopamine transporter variant Val559 transgenic mouse model

Is dopamine transporter-mediated dopaminergic signaling in the retina a noninvasive biomarker for attention-deficit/ hyperactivity disorder? A study in a novel dopamine transporter variant Val559 transgenic mouse model

Abstract Background Dopamine (DA) is a critical neuromodulator in the retina. Disruption of retinal DA synthesis and signaling significantly attenuates light-adapted, electroretinogram (ERG) responses, as well as contrast sensitivity and acuity. As these measures can be detected noninvasively, they...

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Bibliographic Details
Main Authors: Heng Dai, Chad R. Jackson, Gwynne L. Davis, Randy D. Blakely, Douglas G. McMahon
Format: Article
Language:English
Published: BMC 2017-12-01
Series:Journal of Neurodevelopmental Disorders
Subjects:
Biomarker
Dopamine transporter
Electroretinogram
Attention-deficit/hyperactivity disorder
Ala559Val coding substitution
Anomalous dopamine efflux
Online Access:http://link.springer.com/article/10.1186/s11689-017-9215-8

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http://link.springer.com/article/10.1186/s11689-017-9215-8

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