Hypoargininemia exacerbates airway hyperresponsiveness in a mouse model of asthma

Hypoargininemia exacerbates airway hyperresponsiveness in a mouse model of asthma

Abstract Background Asthma is a chronic respiratory condition, with airway hyperresponsiveness (AHR) and inflammation as hallmarks. The hypothesis that the substantially increased expression of arginase 1 in activated macrophages limits the availability of L-arginine for nitric oxide synthesis, and...

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Bibliographic Details
Main Authors: Roy H. E. Cloots, Matthew E. Poynter, Els Terwindt, Wouter H. Lamers, S. Eleonore Köhler
Format: Article
Language:English
Published: BMC 2018-05-01
Series:Respiratory Research
Subjects:
Arginine availability
Lung function
Transgenes
Pulmonary inflammation
Online Access:http://link.springer.com/article/10.1186/s12931-018-0809-9

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http://link.springer.com/article/10.1186/s12931-018-0809-9

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