Preparation and evaluation of Vinpocetine self-emulsifying pH gradient release pellets

Preparation and evaluation of Vinpocetine self-emulsifying pH gradient release pellets

The main objective of this study was to develop a pH gradient release pellet with self-emulsifying drug delivery system (SEDDS), which could not only improve the oral bioavailability of Vinpocetine (VIN), a poor soluble drug, but reduce the fluctuation of plasma concentration. First, the liquid VIN...

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Bibliographic Details
Main Authors: Mengqi Liu, Shiming Zhang, Shuxia Cui, Fen Chen, Lianqun Jia, Shu Wang, Xiumei Gai, Pingfei Li, Feifei Yang, Weisan Pan, Xinggang Yang
Format: Article
Language:English
Published: Taylor & Francis Group 2017-01-01
Series:Drug Delivery
Subjects:
self-emulsifying drug delivery system
ph gradient pellet
oral bioavailability
poorly water-soluble drugs
vinpocetine
Online Access:http://dx.doi.org/10.1080/10717544.2017.1388453

Internet

http://dx.doi.org/10.1080/10717544.2017.1388453

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