Sensitization of ASIC3 by proteinase-activated receptor 2 signaling contributes to acidosis-induced nociception

Sensitization of ASIC3 by proteinase-activated receptor 2 signaling contributes to acidosis-induced nociception

Abstract Background Tissue acidosis and inflammatory mediators play critical roles in pain. Pro-inflammatory agents trypsin and tryptase cleave and activate proteinase-activated receptor 2 (PAR2) expressed on sensory nerves, which is involved in peripheral mechanisms of inflammation and pain. Extrac...

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Bibliographic Details
Main Authors: Jing Wu, Ting-Ting Liu, Yi-Mei Zhou, Chun-Yu Qiu, Ping Ren, Ming Jiao, Wang-Ping Hu
Format: Article
Language:English
Published: BMC 2017-07-01
Series:Journal of Neuroinflammation
Subjects:
Proteinase-activated receptor 2
Acid-sensing ion channel 3
Proton-gated current
Nociception
Dorsal root ganglion neuron
Online Access:http://link.springer.com/article/10.1186/s12974-017-0916-4

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http://link.springer.com/article/10.1186/s12974-017-0916-4

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