ALLOMETRIC ANALYSIS OF THE PHARMACOKINETICS OF FOUR CEPHALOSPORIN ANTIBIOTICS IN MAMMALS

ALLOMETRIC ANALYSIS OF THE PHARMACOKINETICS OF FOUR CEPHALOSPORIN ANTIBIOTICS IN MAMMALS

Allometric analysis of the total body clearance (ClB), steady-state volume of distribution (Vss) and elimination half-life (t1/2) was performed for cephalexin, cefepime, cefquinone and ceftriaxone based on literature data in mammalian species. Values of ClB and Vss show allometric dependence on bod...

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Main Author: L. D. Lashev
Format: Article
Language:English
Published: Faculty of Veterinary Medicine, Trakia University, Stara Zagora, Bulgaria 2017-03-01
Series:Bulgarian Journal of Veterinary Medicine
Online Access:http://tru.uni-sz.bg/bjvm/BJVM-March%202017%20p.27-37.pdf
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spelling doaj-ab704514fc814ce0bc3117baa7559afe2020-11-24T21:16:49ZengFaculty of Veterinary Medicine, Trakia University, Stara Zagora, BulgariaBulgarian Journal of Veterinary Medicine1311-14771313-35432017-03-01201273710.15547/bjvm.950ALLOMETRIC ANALYSIS OF THE PHARMACOKINETICS OF FOUR CEPHALOSPORIN ANTIBIOTICS IN MAMMALSL. D. Lashev0Department of Pharmacology, Physiology and Physiological Chemistry, Faculty of Veterinary Medicine, Trakia University, 6000 Stara Zagora, BulgariaAllometric analysis of the total body clearance (ClB), steady-state volume of distribution (Vss) and elimination half-life (t1/2) was performed for cephalexin, cefepime, cefquinone and ceftriaxone based on literature data in mammalian species. Values of ClB and Vss show allometric dependence on body weight, while values of t1/2 could not be predicted correctly after scaling toward body weight. The equations based on the calculations which could be used for estimation of the respective pharmacoki-netic parameters are as follows: Cephalexin: ClB=0.20W1.05; Vss=0.32W0.98; Cefepime: t1/2β =1.03W0.16; ClB=0.35W0.68; Vss=0.133W0.99; Ceftriaxone: t1/2β=0.83W0.13; ClB=0.76W0.73; Vss=0.82W0.79; Cefqui-nome: ClB=0.22W0.875; Vss=0.298W0.975.http://tru.uni-sz.bg/bjvm/BJVM-March%202017%20p.27-37.pdf
collection DOAJ
language English
format Article
sources DOAJ
author L. D. Lashev
spellingShingle L. D. Lashev
ALLOMETRIC ANALYSIS OF THE PHARMACOKINETICS OF FOUR CEPHALOSPORIN ANTIBIOTICS IN MAMMALS
Bulgarian Journal of Veterinary Medicine
author_facet L. D. Lashev
author_sort L. D. Lashev
title ALLOMETRIC ANALYSIS OF THE PHARMACOKINETICS OF FOUR CEPHALOSPORIN ANTIBIOTICS IN MAMMALS
title_short ALLOMETRIC ANALYSIS OF THE PHARMACOKINETICS OF FOUR CEPHALOSPORIN ANTIBIOTICS IN MAMMALS
title_full ALLOMETRIC ANALYSIS OF THE PHARMACOKINETICS OF FOUR CEPHALOSPORIN ANTIBIOTICS IN MAMMALS
title_fullStr ALLOMETRIC ANALYSIS OF THE PHARMACOKINETICS OF FOUR CEPHALOSPORIN ANTIBIOTICS IN MAMMALS
title_full_unstemmed ALLOMETRIC ANALYSIS OF THE PHARMACOKINETICS OF FOUR CEPHALOSPORIN ANTIBIOTICS IN MAMMALS
title_sort allometric analysis of the pharmacokinetics of four cephalosporin antibiotics in mammals
publisher Faculty of Veterinary Medicine, Trakia University, Stara Zagora, Bulgaria
series Bulgarian Journal of Veterinary Medicine
issn 1311-1477
1313-3543
publishDate 2017-03-01
description Allometric analysis of the total body clearance (ClB), steady-state volume of distribution (Vss) and elimination half-life (t1/2) was performed for cephalexin, cefepime, cefquinone and ceftriaxone based on literature data in mammalian species. Values of ClB and Vss show allometric dependence on body weight, while values of t1/2 could not be predicted correctly after scaling toward body weight. The equations based on the calculations which could be used for estimation of the respective pharmacoki-netic parameters are as follows: Cephalexin: ClB=0.20W1.05; Vss=0.32W0.98; Cefepime: t1/2β =1.03W0.16; ClB=0.35W0.68; Vss=0.133W0.99; Ceftriaxone: t1/2β=0.83W0.13; ClB=0.76W0.73; Vss=0.82W0.79; Cefqui-nome: ClB=0.22W0.875; Vss=0.298W0.975.
url http://tru.uni-sz.bg/bjvm/BJVM-March%202017%20p.27-37.pdf
work_keys_str_mv AT ldlashev allometricanalysisofthepharmacokineticsoffourcephalosporinantibioticsinmammals
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