ALLOMETRIC ANALYSIS OF THE PHARMACOKINETICS OF FOUR CEPHALOSPORIN ANTIBIOTICS IN MAMMALS
Allometric analysis of the total body clearance (ClB), steady-state volume of distribution (Vss) and elimination half-life (t1/2) was performed for cephalexin, cefepime, cefquinone and ceftriaxone based on literature data in mammalian species. Values of ClB and Vss show allometric dependence on bod...
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| Format: | Article |
| Language: | English |
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Faculty of Veterinary Medicine, Trakia University, Stara Zagora, Bulgaria
2017-03-01
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| Series: | Bulgarian Journal of Veterinary Medicine |
| Online Access: | http://tru.uni-sz.bg/bjvm/BJVM-March%202017%20p.27-37.pdf |
| Summary: | Allometric analysis of the total body clearance (ClB), steady-state volume of distribution (Vss) and elimination half-life (t1/2) was performed for cephalexin, cefepime, cefquinone and ceftriaxone based on literature data in mammalian species. Values of ClB and Vss show allometric dependence on body weight, while values of t1/2 could not be predicted correctly after scaling toward body weight. The equations based on the calculations which could be used for estimation of the respective pharmacoki-netic parameters are as follows: Cephalexin: ClB=0.20W1.05; Vss=0.32W0.98; Cefepime: t1/2β =1.03W0.16; ClB=0.35W0.68; Vss=0.133W0.99; Ceftriaxone: t1/2β=0.83W0.13; ClB=0.76W0.73; Vss=0.82W0.79; Cefqui-nome: ClB=0.22W0.875; Vss=0.298W0.975. |
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| ISSN: | 1311-1477 1313-3543 |