Anti-arrhythmic Cardiac Phenotype Elicited by Chronic Intermittent Hypoxia Is Associated With Alterations in Connexin-43 Expression, Phosphorylation, and Distribution

Anti-arrhythmic Cardiac Phenotype Elicited by Chronic Intermittent Hypoxia Is Associated With Alterations in Connexin-43 Expression, Phosphorylation, and Distribution

Remodeling of the cellular distribution of gap junctions formed mainly by connexin-43 (Cx43) can be related to the increased incidence of cardiac arrhythmias. It has been shown that adaptation to chronic intermittent hypobaric hypoxia (IHH) attenuates the incidence and severity of ischemic and reper...

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Main Authors: Jana Kohutova, Barbara Elsnicova, Kristyna Holzerova, Jan Neckar, Ondrej Sebesta, Jana Jezkova, Marek Vecka, Pavel Vebr, Daniela Hornikova, Barbara Szeiffova Bacova, Tamara Egan Benova, Marketa Hlavackova, Narcis Tribulova, Frantisek Kolar, Olga Novakova, Jitka M. Zurmanova
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-01-01
Series:Frontiers in Endocrinology
Subjects:
heart
chronic hypoxia
brief ischemia
arrhythmia
connexin-43
n-3 PUFA
Online Access:https://www.frontiersin.org/article/10.3389/fendo.2018.00789/full

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https://www.frontiersin.org/article/10.3389/fendo.2018.00789/full

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