Intranasal delivery of experimental compounds in orthotopic brain tumor mouse models

Intranasal delivery of experimental compounds in orthotopic brain tumor mouse models

Summary: Effective therapeutics for malignant primary brain tumors, such as glioblastomas (GBMs), are urgently needed. To facilitate and expedite early-phase GBM therapeutic development, we describe a protocol that allows the intranasal delivery of experimental compounds in GBM orthotopic mouse mode...

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Bibliographic Details
Main Authors: Katharina M. Eyme, Litia Carvalho, Christian E. Badr
Format: Article
Language:English
Published: Elsevier 2021-03-01
Series:STAR Protocols
Subjects:
Cancer
Model organisms
Neuroscience
Online Access:http://www.sciencedirect.com/science/article/pii/S266616672030277X
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spelling doaj-ab5d446ecb2048568fa2891d60e6d89e2021-03-22T12:53:02ZengElsevierSTAR Protocols2666-16672021-03-0121100290Intranasal delivery of experimental compounds in orthotopic brain tumor mouse modelsKatharina M. Eyme0Litia Carvalho1Christian E. Badr2Department of Neurology, Massachusetts General Hospital, Boston, MA 02129, USADepartment of Neurology, Massachusetts General Hospital, Boston, MA 02129, USA; Neuroscience Program, Harvard Medical School, Boston, MA, USADepartment of Neurology, Massachusetts General Hospital, Boston, MA 02129, USA; Neuroscience Program, Harvard Medical School, Boston, MA, USA; Corresponding authorSummary: Effective therapeutics for malignant primary brain tumors, such as glioblastomas (GBMs), are urgently needed. To facilitate and expedite early-phase GBM therapeutic development, we describe a protocol that allows the intranasal delivery of experimental compounds in GBM orthotopic mouse models. Compounds delivered through this route can bypass the blood-brain barrier and thus help validate effective therapeutic targets for GBMs.For complete details on the use and execution of this protocol, please refer to Pinkham et al. (2019).http://www.sciencedirect.com/science/article/pii/S266616672030277XCancerModel organismsNeuroscience
collection DOAJ
language English
format Article
sources DOAJ
author Katharina M. Eyme
Litia Carvalho
Christian E. Badr
spellingShingle Katharina M. Eyme
Litia Carvalho
Christian E. Badr
Intranasal delivery of experimental compounds in orthotopic brain tumor mouse models
STAR Protocols
Cancer
Model organisms
Neuroscience
author_facet Katharina M. Eyme
Litia Carvalho
Christian E. Badr
author_sort Katharina M. Eyme
title Intranasal delivery of experimental compounds in orthotopic brain tumor mouse models
title_short Intranasal delivery of experimental compounds in orthotopic brain tumor mouse models
title_full Intranasal delivery of experimental compounds in orthotopic brain tumor mouse models
title_fullStr Intranasal delivery of experimental compounds in orthotopic brain tumor mouse models
title_full_unstemmed Intranasal delivery of experimental compounds in orthotopic brain tumor mouse models
title_sort intranasal delivery of experimental compounds in orthotopic brain tumor mouse models
publisher Elsevier
series STAR Protocols
issn 2666-1667
publishDate 2021-03-01
description Summary: Effective therapeutics for malignant primary brain tumors, such as glioblastomas (GBMs), are urgently needed. To facilitate and expedite early-phase GBM therapeutic development, we describe a protocol that allows the intranasal delivery of experimental compounds in GBM orthotopic mouse models. Compounds delivered through this route can bypass the blood-brain barrier and thus help validate effective therapeutic targets for GBMs.For complete details on the use and execution of this protocol, please refer to Pinkham et al. (2019).
topic Cancer
Model organisms
Neuroscience
url http://www.sciencedirect.com/science/article/pii/S266616672030277X
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AT litiacarvalho intranasaldeliveryofexperimentalcompoundsinorthotopicbraintumormousemodels
AT christianebadr intranasaldeliveryofexperimentalcompoundsinorthotopicbraintumormousemodels
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