Lack of PPARγ in myeloid cells confers resistance to Listeria monocytogenes infection.

The peroxisomal proliferator-activated receptor γ (PPARγ) is a nuclear receptor that controls inflammation and immunity. Innate immune defense against bacterial infection appears to be compromised by PPARγ. The relevance of PPARγ in myeloid cells, that organize anti-bacterial immunity, for the outco...

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Main Authors: Zeinab Abdullah, Sergej Geiger, Andrea Nino-Castro, Jan P Böttcher, Eugenia Muraliv, Moritz Gaidt, Frank A Schildberg, Kati Riethausen, Juliane Flossdorf, Wolfgang Krebs, Trinad Chakraborty, Christian Kurts, Joachim L Schultze, Percy A Knolle, Luisa Klotz
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22629382/pdf/?tool=EBI