CP-346086

CP-346086

A microsomal triglyceride transfer protein (MTP) inhibitor, CP-346086, was identified that inhibited both human and rodent MTP activity [concentration giving half-maximal inhibition (IC50) 2.0 nM]. In Hep-G2 cells, CP-346086 inhibited apolipoprotein B (apoB) and triglyceride secretion (IC50 2.6 nM)...

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Bibliographic Details
Main Authors: Charles E. Chandler, Donald E. Wilder, Judith L. Pettini, Yvette E. Savoy, Stephen F. Petras, George Chang, John Vincent, H. James Harwood, Jr.
Format: Article
Language:English
Published: Elsevier 2003-10-01
Series:Journal of Lipid Research
Subjects:
microsomal triglyceride transfer protein
lipid transfer inhibition
very low density lipoprotein
low density lipoprotein
apolipoprotein B
apolipoprotein A-I
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520337068

Internet

http://www.sciencedirect.com/science/article/pii/S0022227520337068

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